Malignant hyperpyrexia occurring in a second Johannesburg family.

A further family carrying the abnormality for malignant hyperpyrexia has been studied over four generations. The carriers with one exception have been identified by creatine phosphokinase estimations. In one branch of this family two grandchildren exhibit multiple musculoskeletal abnormalities and in addition a high creatine phosphokinase. The rest of the family was clinically normal though many carried the predisposing tendency for malignant hyperpyrexia as shown by elevated creatine phosphokinase levels. The case of a member of this family who survived two malignant hyperpyrexial episodes is presented.